inflammatory_markers
Inflammatory Markers
C-reactive protein (CRP)
- changes rapidly in response to inflammatory stimulus starting to rise in 4-6/24 and peaking in 36-50/42
- half life 24/24
- need to be interpreted in context and trending results are more important
- high levels usually associated with:
- acute infections
- malignancies
- myocardial infarction
- pancreatitis
- Persistent elevation associated with chronic inflammatory conditions:
- chronic infections eg bronchitis or hepatitis
- inflammatory arthritide eg. rheumatoid arthritis
- Systemic inflammation eg RA, SLE, other autoimmune diseases
- Minor elevation seen with many conditions:
- obesity
- pregnancy
- depression
- diabetes
- cardiovascular disease.
Neutrophil to Lymphocyte ratio (NLR)
| NLR | Interpretation | Conditions |
|---|---|---|
| 0.1-0.7 | Neutropenia | |
| 1-2 | Normal | |
| 2-3 | Mild inflamm | autoimmune chr disease malignancy psych disorders Covid CVS disease diabetes |
| 3-7 | mild to mod inflamm | |
| 7-11 | Mod to severe | Sepsis severe Covid SIRS |
| 11-17 | severe inflamm | Sepsis, SIRS, bacteraemia |
| >17 | Critical inlamm | septic shock trauma advanced malig post-op |
Author: Dr Dylan Jenkins, Oct 2023